Integrative Cell Models for Disease Intervention (18w5073)


Matthew Scott (University of Waterloo)

(University of Minnesota)

Peter Swain (University of Edinburgh (UK))


The Banff International Research Station will host the "Integrative Cell Models for Disease Intervention" workshop from June 10th to June 15th, 2018.

Biological processes do not occur in isolation and their appropriate execution requires communication and coordination across the cell. We know that signals are conveyed via interactions between proteins and between proteins and DNA, but such regulatory interactions are not the sole drivers of cellular responses. Changes in the physiological composition of the cell and particularly in the levels of common resources, such as energy and raw materials, also, just as in the human economy, provides a higher level of regulation. The extent of the control provided by this potentially primordial regulation has only recently been appreciated. Yet its effects are felt widely, ranging from the development of antibiotic resistance to the production of chemicals in the biotechnology industry. The broad ambition of this workshop is to foster the development of a new mathematical framework for modeling cellular processes that includes global regulation, either implicitly or explicitly, and so enables quantitative prediction particularly focused on disease intervention.

The Banff International Research Station for Mathematical Innovation and Discovery (BIRS) is a collaborative Canada-US-Mexico venture that provides
an environment for creative interaction as well as the exchange of ideas, knowledge, and methods within the Mathematical Sciences, with related disciplines and with industry. The research station is located at The Banff Centre in Alberta and is supported by Canada's Natural Science and Engineering Research Council (NSERC), the U.S. National Science Foundation (NSF), Alberta's Advanced Education and Technology, and Mexico's Consejo Nacional de Ciencia y Tecnología (CONACYT).